MUPS Tab.
Seclo MUPS
Omeprazole (MUPS tablet)
— Square Pharmaceuticals Ltd.
20mg / mups tablet
Presentations
MUPS Tablet · 20mg / mups tablet
1 mups tablet
৳7
Dose rules
No structured dose rules are linked to this brand yet.
Dose reference
Human
Adult: GERD (Gastroesophageal Reflux Disease): 20 mg once daily for 4 weeks. Gastric ulcer: 20 mg once daily for 4-8 weeks; in severe cases Twice daily. Duodenal ulcer: 20 mg once daily for 2-4 weeks; in severe cases Twice daily. NSAID-induced ulceration: 20 mg once daily for 4-8 weeks. Reflux esophagitis: 20 mg once daily for 4-8 weeks; in severe cases Twice daily. H. pylori eradication (Omeprazole MUPS tablet with Amoxicillin and Clarithromycin or Metronidazole): 20 mg twice daily for 1 week. Zollinger-Ellison Syndrome: 60 mg once daily; Usual maintenance, 20-120 mg daily. Children over 2 years old: Acid regurgitation in GERD (Gastroesophageal Reflux Disease): 20 mg once daily for 2-4 week. Reflux esophagitis: 20 mg once daily for 4-8 weeks.
Administration: Take the tablet before or after a meal. Swallow the tablet whole with a glass of water. The tablet must not be chewed or crushed. OR If the patients have trouble swallowing the tablets, put the tablet into a glass of water (Do not use other liquids). Stir the preparation until the tablets disintegrate. Then drink the liquid within 30 minutes. Stir the mixture just always before drinking.
Clinical notes
Applications:
- Zollinger-Ellison syndrome
Indication Notes:
Omeprazole MUPS tablet is indicated in- Duodenal and Gastric ulcers NSAID-induced gastric and duodenal ulcers Reflux Oesophagitis GERD (Gastroesophageal Reflux Disease) Eradication of H. pylori with appropriate antibiotics Zollinger-Ellison Syndrome
Avoid In:
N/A
Contraindication Notes:
Omeprazole is contraindicated in those patients who have known hypersensitivity to any other components of the formulation.
MUPS is abbreviation for Multiple-Unit Pellet System. However, from pharmaceutical industry and research perspective, the term in general refers to MUPS compacted into tablets. Thus, the resulting tablets prepared by compaction of modified release coated multiparticulates or pellets are called as MUPS. It is the more recent and challenging technology that combines the advantages of both tablets and pellet-filled capsules in one dosage form.Clinical advantage of omeprazole MUPS tablet compared to conventional modified-release omeprazole tablets and pellet-filled omeprazole capsules: Ensures greater bioavailability Ensures uniform emptying of micro pellets from stomach into small intestine facilitates rapid dissolution of enteric coating and drug release resulting in early Tmax and Cmax (peak time and peak plasma concentration) Ensures lesser possibility of dose dumping Is a combination of fast acting and sustained action Ensures uniform drug release Once daily dosing Ensures lesser chance of localized irritation Ensures better and more uniform drug absorption Better than capsules in reducing the esophageal residence time Minimizes fluctuation in plasma concentration of drug. Pharmacodynamic advantage: MUPS ensure rapid and uniform gastric emptying and subsequently uniform drug dissolution of pellets in the gastrointestinal tract due to their small size and larger surface, uniform drug absorption is facilitated which results in consistent and controlled pharmacological action. A further reduction in inter-and intra-subject variability in drug absorption and clinical response is facilitated since the number of pellets per MUPS dosage form is much more than a conventional pellet-filled capsule and possibility of dose dumping(in stomach) and incomplete drug release is further minimized.
Omeprazole is metabolized through CYP2C19 . When starting or stopping treatment with Omeprazole should be taken into account potential interactions with medicines which are CYP2C19 metabolized.
Not known to be harmful. Omeprazole can be used during pregnancy. Omeprazole is excreted in breast milk but is not likely to influence the child when therapeutic doses are used.
Omeprazole tablet should be used carefully if the patient has severe liver dysfunction and severe renal impairment.