Synogen

• Osteoarthritis (degenerative arthritis)

Undenatured Type II Collagen capsule is indicated for- Osteoarthritis Rheumatoid arthritis Joint pain & inflammation Difficulties in flexibility & mobility Joint discomfort & stiffness (knee extension) Impaired joint function Strenuous exercise & sports

N/A

Contraindicated in patients with known hypersensitivity to chicken or egg.

Undenatured Type II Collagen derived from chicken sternum cartilage using a patented, low-temperature, non-enzymatic manufacturing process that preserves the natural triple helix molecular configuration and its biological activity. Undenatured collagen II has unique mechanism of action. Undenatured collagen II molecules contain active binding sites called epitopes which trigger the process of oral tolerization. Through oral tolerization process, active epitopes of undenatured collagen II interact with Peyer’s patches (lymphoid tissue) of small intestine to release collagen-specific regulatory T-cells. Collagen-specific regulatory T-cells then migrate to joint areas and prevent release of T-cells.Preventing the release of T-cells prevent the secretion of collagenase enzymes by macrophages responsible for breakdown of collagen in joint cartilage. It also slows the production of inflammatory cytokines resulting in reduction of inflammation, halting the erosion of joint cartilage and promote cartilage rebuilding. Undenatured Type II Collagen supports joint function, mobility and flexibilityand  also improves knee extension by up to 10% for better range of motion. It also relieves joint pain due to strenuous exercise.

Not known.

Undenatured Type II Collagen is generally well tolerated in recommended dose. Over dose may cause constipation and headache.

Lack of scientific evidence on the use of undenatured collagen II during pregnancy or lactation.