Bol. Tolfavet
Bolus · PO · 200mg Tolfenamic Acid · 200 mg
৳20
Bol.
Tolfavet
Tolfenamic acid
— Techno Drugs Ltd.
200mg Tolfenamic Acid
Presentations
Dose rules
No structured dose rules are linked to this brand yet.
Dose reference
Cat
4 mg/kg once daily SC, IM or PO for 3–5 days. The injectable is suggested for the first dose only.
Cattle
2 mg/kg by IM injection high in the neck. Treatment may be repeated once only after 48 hours.
Mastitis: 4 mg/kg as a single intravenous injection.
Dog
For acute pain: 4 mg/kg once daily SC, IM or PO for 3–5 days.
For chronic pain: 4 mg/kg, PO once daily for 3–5 consecutive days per week. The injectable is suggested for the first dose only.
Sheep
2 mg/kg by IM injection high in the neck. Treatment may be repeated once only after 48 hours.
Mastitis: 4 mg/kg as a single intravenous injection.
Goat
2 mg/kg by IM injection high in the neck. Treatment may be repeated once only after 48 hours.
Mastitis: 4 mg/kg as a single intravenous injection.
Human
Adult: Acute migraine attacks: 200 mg when symptoms appear may be repeated once after 1-2 hour. Mild to moderate pain: 100-200 mg tid Renal impairment: Dose adjustments may be needed. Severe renal impairment: Avoid. Children: A pediatric dosage regimen has not yet been established.Tolfenamic acid should be taken with food. Take water during or immediately after meals.
Swine
2 mg/kg IM once
Clinical notes
Applications:
N/A
Indication Notes:
Tolfenamic acid is used specifically for relieving the pain of migraine headache and also recommended for use as an analgesic in post-operative pain and fever.
Avoid In:
N/A
Contraindication Notes:
Active peptic ulcer or bleeding in the gut. Severe heart, kidney or liver failure.
Tolfenamic acid (N-(2-methyl-3-chlorophenyl) anthranilic acid) belongs to the fenamate group and is a potent inhibitor of cyclooxygenase enzyme, thus it inhibits the synthesis of important inflammatory mediators such as thromboxane (TX) B2 and prostaglandin (PG) E2. Prostaglandins are responsible for causing swelling pain and inflammation associated with these conditions. It acts not only by inhibiting prostaglandin synthesis, but it also has direct antagonistic action on its receptors.Pharmacokinetic properties: Absorption Readily absorbed from GI tract. Peak plasma concentration: 60-90 min. Bioavailability 85%. Distribution: Protein-binding: 99% Plasma half-life 2 hours. Metabolism: Metabolised in the liver. Tolfenamic acid undergoes enterohepatic circulation. Excretion: Excreted in urine (90%) and faces.
The rate of absorption of Tolfenamic acid increases with Metoclopramide and Magnesium hydroxide but decreases with Aluminium hydroxide. Risk of bleeding with anticoagulants and other NSAIDS increases when use with Tolfenamic acid. It decreases antihypertensive response to loop diuretics, B-blockers and ACE Inhibitors. Co-administration increases plasma concentration of Lithium Methotrexate and cardiac glycosides. It also increases the risk of nephrotoxicity with ACE inhibitors, Ciclosporin, Tacrolimus or diuretics
Dysuria especially in males, diarrhoea, nausea epigastric pain, vomiting, dyspepsia, erythema, headache, tremor, euphoria, fatigue, pulmonary infiltration & haematuria. Potentially fatal: Blood dyscrasias and hepatitis.
Symptoms include headache, nausea, vomiting, epigastric pain. gastrointestinal bleeding, diarrhoea excitation, coma, drowsiness dizziness, tinnitus, fainting and convulsions. In cases of significant poisoning, acute renal failure and liver damage are possible. Patients should be treated symptomatically as required.
This medicine is not recommended for using during pregnancy unless considered essential by doctor Not to be given during the third trimester of pregnancy. NSAID's can appear in breast milk in very low concentrations NSAID's should, if possible, be avoided when breastfeeding.
Precaution should be needed for patients with asthma bronchospasm, bleeding disorders, cardiovascular diseases, peptic ulceration, hypertension, liver infection, cardiac or renal function impairment and elderly. Increase water intake or dose reduction to reduce dysuria.