Pow.
Tylosin
— Incepta Pharmaceuticals LTD.
200mg Tylosin
· 100 gm
Powder · Oral · 200mg Tylosin · 100 gm
৳232
No structured dose rules are linked to this brand yet.
Cat
a) For adjunctive treatment of IBD: 10 mg/kg PO three times daily. Therapeutic trial for 21 days to evaluate efficacy. (Simpson 2003)
b) For treatment of IBD or diarrheas caused by C. perfringens: 20–40 mg/kg PO twice daily (Marks 2002)
c) For IBD: 40 mg/kg PO q12h (Zoran 2007)
d) For clostridial colitis: 10–40 mg/kg PO twice daily. Practically (using the wettable powder): 1/16th of teaspoon 2–3 times daily. Mix with food to hide unpleasant taste or put into capsules. Animals with chronic clostridial colitis can often be controlled with one treatment every 2–3 days. (Willard 2006)
Cattle
For susceptible infections:
a) 17.6 mg/kg IM once daily. Continue treatment for 24 hours after symptoms have stopped, not to exceed 5 days. Do not inject more than 10 mL per site. Use the 50 mg/mL formulation in calves weighing less than 200 pounds. (Package insert; Tylosin® Injection—TechAmerica)
b) For bronchopneumonia and fibrinous pneumonia in cattle associated with penicillin G-refractory C. pyogenes infections or other bacteria sensitive to tylosin and resistant to sulfas, penicillin G and tetracyclines: using Tylosin 200 mg/mL: 44 mg/kg IM q24h. Recommend a 21-day slaughter withdrawal at this dosage. (Hjerpe 1986)
c) 5–10 mg/kg IM or slow IV once daily; not to exceed 5 days (Huber 1988)
d) Tylosin base injectable: 10 mg/kg IM initially, then 6 mg/kg IM q8h (q8–12h in calves) (Baggot 1983)
Dog
a) For small intestinal bacterial overgrowth: 10–20 mg/kg PO q12h; recommended for chronic cases, may require therapy for as long as 6 weeks. (Ludlow & Davenport 2000)
b) For adjunctive treatment of IBD: 10 mg/kg PO three times daily. Therapeutic trial for 21 days to evaluate efficacy. (Simpson 2003)
c) For clostridial colitis: 10–40 mg/kg PO twice daily. Practically (using the wettable powder): 1/16th of teaspoon 2–3 times daily for dogs (<7kg); ⅛th of a teaspoon 2–3 times a day for medium dogs (7–15 kg); and ¼ teaspoon 2–3 times a day for larger dogs (>15 kg). Mix with food to hide unpleasant taste or put into capsules. Animals with chronic clostridial colitis can often be controlled with one treatment every 2–3 days. (Willard 2006)
d) For IBD and antibiotic responsive diarrhea: 20–40 mg/kg PO q12h (Marks 2007)
e) 25 mg/kg PO once daily (in the study dogs were treated for 7 days, but the authors state that in dogs with tylosin-responsive diarrhea the stool remains normal as long as treatment continues, but diarrhea reappears within weeks after discontinuation). (Kilpienn et al. 2009)
Sheep
For susceptible infections:
a) 10 mg/kg, treatment not to exceed 5 days (Huber 1988)
Goat
For susceptible infections:
a) 10 mg/kg, treatment not to exceed 5 days (Huber 1988)
Ferrets
10 mg/kg PO once to twice daily (Williams 2000)
Rabbit
10 mg/kg PO, SC, IM q12–24h (Ivey & Morrisey 2000)
Reptiles (Large)
For susceptible infections:
a) For tortoises: 5 mg/kg IM once daily for at least 10 days. Used primarily for chronic respiratory infections or when Mycoplasma is suspected (Gauvin 1993)
b) All species: 5 mg/kg IM once daily (Jacobson 1999)
Birds (Other)
For susceptible infections:
a) For initial therapy in caged birds for upper respiratory infections (especially if mycoplasma suspected). Using 200 mg/mL injectable: 40 mg/kg IM. Used in combination with aminoglycosides. (McDonald 1989)
b) For initial therapy of upper respiratory infections and air sacculitis. Using 50 mg/mL or 200 mg/mL injectable: 10–40 mg/kg IM twice daily or three times daily (Clubb 1986)
c) 30 mg/kg IM q12h (Hoeffer 1995)
Small mammals
Gerbils, Hamsters, Rats: 10 mg/kg SC q24h (Adamcak & Otten 2000)
In cattle, tylosin is used for treatment of BRD caused by Mannheimia spp., P. multocida, and H. somni. It is used for interdigital necrobacillosis (foot rot) in cattle caused by F. necrophorum or B. melaninogenicus. In pigs, it is used for treatment of swine arthritis caused by Mycoplasma hyosynoviae, swine pneumonia caused by Pasteurella spp., swine erysipelas caused by Erysipelothrix rhusiopathiae, swine dysentery associated with Serpulina (Treponema) hyodysenteriae, and proliferative enteropathy caused by L. intracellularis. For treatment in pigs, it is also added to feed (type A–medicated feed article) or drinking water. In small animals, it is used for gram-positive soft tissue and skin infections. However, this use is uncommon, and the most frequent use in dogs is for treatment of diarrhea, referred to as antibiotic-responsive diarrhea, that has not responded to other treatments. The etiology of the diarrhea is not known but may be caused by Clostridium or Campylobacter spp. For this use, the powdered formulation (swine formulation) has been added to food daily for maintenance.
N/A
Do not administer orally to rodents or rabbits. Do not administer to horses.
to 50S ribosome and inhibits protein synthesis) and exhibits a similar spectrum of activity. It is a bacteriostatic antibiotic. Tylosin may also have immunomodulatory effects on cell-mediated immunity. In dogs, tylosin increases concentrations of enterococci (Enterococcus fecalis) in the jejunum. Enterococci are thought to have probiotic effects.
Clostridium and Campylobacter spp. are usually susceptible. The spectrum also includes the bacteria that cause BRD. E. coli and Salmonella spp. are resistant. In pigs, Lawsonia intracellularis is usually susceptible.
Drug interactions with tylosin have not been well documented. It has been suggested that tylosin may increase digoxin blood levels with resultant toxicity.
It is suggested to refer to the erythromycin monograph for more information on potential interactions.
Tylosin may cause diarrhea in some animals. However, for oral treatment for colitis in dogs, it has been administered for several months with safety. Skin reactions have been observed in pigs. Oral administration to horses has been fatal.
In a system evaluating the safety of drugs in canine and feline pregnancy (Papich 1989), this drug is categorized as in class: B (Safe for use if used cautiously. Studies in laboratory animals may have uncovered some risk, but these drugs appear to be safe in dogs and cats or these drugs are safe if they are not administered when the animal is near term.)
Avoid IV administration. Do not inject more than 10 mL in one IM site to avoid
local reactions.
Meat: 21days
Milk: 7 days
Store below 30° C and dry place, protected from light. Keep all medicines out of reach of children.