Inj., Susp., Tab.

Vorifast

Voriconazole — Healthcare Pharmaceuticals Ltd.
200mg / vial · 200mg / 5ml · 200mg · 50mg

Alternatives

21

Routes

IV, PO

Presentations

4

Generic profile Browse alternatives View combinations

Presentations

Inj. Vorifast

IV Injection · Intravenous · 200mg / vial · 1 vial

৳2000

Susp. Vorifast

Powder for Suspension · Oral · 200mg / 5ml · 40 ml

৳1000

Dose rules

No structured dose rules are linked to this brand yet.

Dose reference

Human

Oral-Voriconazole tablet and powder for suspension are to be taken at least one hour before or one hour following a meal At or over 40 kg body weight: Loading dose regimen is 400 mg or 10 ml every 12 hours (for the first 24 hours) and maintenance dose (after first 24 hours) is 200 mg or 5 ml twice daily. Below 40 Kg body weight: Loading dose regimen is 200 mg or 5 ml every 12 hours (for the first 24 hours) and maintenance dose (after first 24 hours) is 100 mg or 2.5 ml twice daily. Or, as directed by the registered physician. Injection-Invasive Aspergillosisd : Loading dose: 6 mg/kg 12 hourly for the first 24 hours. Maintenance Dose: 4 mg/kg 12 hourly. Candidemia in nonneutropenic patients and other deep tissue Candida infections: Loading dose: 6 mg/kg 12 hourly for the first 24 hours. Maintenance Dose: 3-4 mg/kg 12 hourly. Scedosporiosis and Fusariosis: Loading dose: 6 mg/kg 12 hourly for the first 24 hours. Maintenance Dose: 4 mg/kg 12 hourly.

Clinical notes

Applications:
  • Scedosporiosis and fusariosis
Indication Notes:
Voriconazole is an azole antifungal medicine. It is indicated for use in patients 12 years of age and older in the treatment of following fungal infections- Invasive aspergillosis Candidemia (nonneutropenic) and disseminated candidiasis in skin, abdomen, kidney, bladder wall and wounds ... Read moreVoriconazole is an azole antifungal medicine. It is indicated for use in patients 12 years of age and older in the treatment of following fungal infections- Invasive aspergillosis Candidemia (nonneutropenic) and disseminated candidiasis in skin, abdomen, kidney, bladder wall and wounds Esophageal candidiasis Serious infections caused by Scedosporium apiospermum and Fusarium Species including Fusarium solani Patients intolerant of, or refractory to other therapy.
Avoid In:

N/A

Contraindication Notes:
Known hypersensitivity to Voriconazole or any other components of this drug- Co-administration with terfenadine, astemizole, cisapride, pimozide or quinidine, sirolimus due to risk of serious adverse reactions Co-administration with rifampin, carbamazepine, long-acting barbiturates, efavirenz, ritonavir, rifabutin, ergot alkaloids and St. John's Wort due to risk of loss of efficacy
Voriconazole is a triazole antifungal medication used to treat serious fungal infections. Voriconazole binds and inhibits ergosterol synthesis by inhibiting CYP450-dependent 14-alpha sterol demethylase. The inhibition of 14-alpha sterol demethylase results in a depletion of ergosterol in fungal cell membrane.
CYP3A4, CYP2C9 and CYP2C19 inhibitors and inducers: Adjust Voriconazole dosage and monitor for adverse reactions or lack of efficacy Voriconazole may increase the concentrations and activity of drugs that are CYP3A4, CYP2C9 and CYP2C19 substrates. Reduce doses of these other drugs and monitor for adverse reactions Increase maintenance oral and intravenous dosage of Voriconazole with co-administration of Phenytoin or Efavirenz
The most common side effects are abdominal pain, anemia, blurred vision, headache, chest pain, nausea and diarrhea.
There is no data found about overdose of Voriconazole.
There are no adequate and well-controlled studies in pregnant woman. It should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
Long term exposure (treatment or prophylaxis) greater than 180 days requires careful assessment of the benefit-risk balance. Squamous cell carcinoma of the skin (SCC) has been reported in relation with long-term voriconazole treatment.
The efficacy to the children under 12 years of age is not established.

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