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Generic Drug: Erythromycin + Sulphadiazine + Trimethoprim

View Alternative Brand Names (3)
Composition: Each gm powder contains Erythromycin thiocyanate INN 180 mg, Sulphadiazine BP 150 mg & Trimethoprim BP 30 mg.

Drug Class: Antibiotic

Manufacturer: Incepta Pharmaceuticals LTD.

Basic information

Generic Drug

Erythromycin + Sulphadiazine + Trimethoprim

Route of Administration

PO

Strength / Concentration

180 mg + 150 mg + 30 mg /gm

Presentation and price

100 gm sachet

420 Taka

500 gm sachet

1850 Taka

Dose and dosage

Cattle

 Calves : 7.5 g per 50 kg body weight, for 3-5 days.
Horse

Foals : 7.5 g per 50 kg body weight, for 3-5 days.
Fish (Large)

1 g per 10 kg body weight, for 3-5 days
Poultry

0.5 to 1.0 gm per litter of drinking water for 3-5 days

Applications:
  • Pullorum
  • Necrotic Enteritis
  • Urogenital Tract Diseases
  • Fowl Typhoid
  • Fowl Cholera
  • Colibacillosis
  • Septicemia
  • Enteritis
  • Mycoplasmosis (CRD)
  • Bronchopneumonia
  • Coccidiosis
  • Diarrhea
  • scours
Indication Notes:

When other antibiotics and chemotherapeutics fail due to resistance problem. Calves & foals: indicated in respiratory & gastro-intestinal tract infections like bronchopneumonia, bronchitis, diarrhea, enteritis & scour. 

Fish: gram-positive cocci infections of fish. 

Avoid In:

N/A

Contraindication Notes:

 contraindicated in animals with hypersensitivity to the erythromycin, Sulphadiazine & Trimethoprim. 

This combination provides broad spectrum activity against a wide range of bacterial & some protozoal infections. Erythromycin is a macrolide antibiotic highly effective against gram positive bacteria, and Mycoplasma. It is also effective against some gram-negative bacteria such as Nessaria spp. & Haemophilus spp. Erythromycin works by binding with 50s ribosomal subunit, consequently inhibit protein synthesis of bacteria. Sulphadiazine inhibits biosynthesis of PABA to dihydrosulphonic acid & Trymethoprim inhibits the biosynthesis of tetrahydrofolic acid from dihydrofolic acid. 

 With medicine: Should not be used concurrently with macrolide antibiotic, chloramphenicol, Tylosin & Lincosomide. 

With food & others: In the case of erythromycin, there are no specific foods that should exclude from diet when receiving this medication. 

 Common side effects: No side effects observed at recommended doses. Rare side effects: No side effects observed at recommended doses. 

 This drug is relatively non-toxic. 

 May be used in pregnant & lactating animals but risk & benefit may be considered. 

 Oral erythromycin should not be used in ruminants as diarrhea may occur. 

 Egg 6 days, Meat: 5 days. 

 Store below 300 C temperature and dry place, protected from light. Keep all medicines out of reach of children.